[photo] Morteza Mahmoudi, Ph.D.

Morteza Mahmoudi, Ph.D.

Assistant Professor

Department of Radiology

Precision Health Program

 

mahmou22@msu.edu

517.353.0543

Lab Website

 

Precision Health Program, IQ Building

775 Woodlot Drive

East Lansing, MI 48824

College Degrees: 

Ph.D.: Nanoscience and Nanotechology, Sharif University of Technology, Tehran, Iran, 2009
M.S.: Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran, 2006

B.S.: Materials Science and Engineering, University of Tehran, Tehran, Iran, 2002


Research Interests:

Dr. Morteza Mahmoudi is an Assistant Professor of Radiology and Precision Health Program at Michigan State University (MSU). Prior coming to MSU, he was an Assistant Professor of Anesthesiology at Brigham and Women’s Hospital, Harvard Medical School. His specific research interest is in nanomedicine and regenerative medicine for the development of new nano-based platforms for prevention/treatment of life-threatening conditions such as cardiomyopathy, cancer, and neurodegenerative diseases. Aside from nanomedicine and regenerative medicine, Dr. Mahmoudi is also very active in social sciences and specifically in drawing the attention of the scientific community in the rising issue of academic bullying. In addition, he is also working on identifying the reasons behind the enormous disparity between the numbers of major prize winners between the sexes (which currently stands at more than an order of magnitude in favor of male nominees) and seek to draw the attention of award agencies, researchers, entrepreneurs, and media to reexamine the historical imbalances between the sexes in winning major scientific awards. He is among 2018 highly cited researchers as reported by Clarivate Analytics.


 

 

Academic Research and Professional Positions

Assistant Professor, Precision Health Medicine and Department of Radiology; Michigan State University, East Lansing, MI 2019

Assistant Professor, Department of Anesthesiology; Harvard Medical School, Boston, MA (BWH) 2018-2019

Assistant Professor, Center for Nanomedicine & Department of Anesthesiology; Brigham and Women's Hospital, Boston, MA 2018-2019

Instructor; Department of Anesthesiology; Harvard Medical School, Boston, MA 2016-2018

Instructor; Center for Nanomedicine & Department of Anesthesiology; Brigham and Women's Hospital, Boston, MA (BWH) 2016-2018

Postdoctoral Fellow; Cardiovascular Medicine, Stanford School of Medicine, Palo Alto, CA 2014-2015

Visiting Professor, Department of Pediatric Cardiology, Stanford School of Medicine, Palo Alto, CA 2013-2014

Assistant Professor; Nanotechnology Research Center and Department of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran 2011-2016

Visiting Professor, Department of Chemistry, The University of Illinois at Urbana-Champaign 2012

Research Trainee; Center for BioNano Interactions, University College Dublin, Ireland 2011

Postdoctoral Fellow; Cellular and Molecular Biology, Pasteur Institute, Iran 2009-2010

Research Trainee; Laboratory of Powder Technology, Ecole Polytechnique Federale de Lausanne, Switzerland 2009

 

Selected Publications

  • H-Index and Citations: >190 scientific papers, 4 books edited, and 11 patents and patents pending.
  • h-index = 63 (i.e., 63 publications each with 63 or more citations); >70 citations/journal paper.
  • Total citations: >17,200. i10-index = 159 (# papers with ≥10 citations).
  • Top Journals: Nature, Lancet, Nature Nanotechnology, Nature Communications, and Nature Biomedical Engineering.
 

Biomolecular Corona, Biological Identity of Nanotechnologies, and Hidden Factors at NanBio Iterface

  1. M. Mahmoudi*, “Debugging Nano–Bio Interfaces: Systematic Strategies to Accelerate Clinical Translation of Nanotechnologies”, Trends in Biotechnology, 2018, 36, 755-769.
  2. S. Behzadi, V. Serpooshan, W. Tao, M. Hamaly, M. Alkawareek, E. Dreaden, D. Brown, Al. Alkilany, O. Farokhzad*, M. Mahmoudi* “Cellular uptake of nanoparticles: journey inside the cell”, Chemical Society Reviews, 2017, 46, 4218-4244 (with cover).
  3. G. Caracciolo, O. Farokhzad*, M. Mahmoudi*, “Biological identity of nanoparticles in vivo: clinical implications of the protein corona”, Trends in Biotechnology, 2017, 35, 257–264.
  4. K. Saha, M. Rahimi, M. Yazdani, S. T. Kim, D. Moyano, S. Hou, R. Das, R. Mout, F. Rezaee, M. Mahmoudi*, V. Rotello*, “Regulation of Macrophage Recognition through the Interplay of Nanoparticle Surface Functionality and Protein Corona”, ACS Nano, 2016, 10, 4421–4430.
  5. A. Bigdeli, S. Palchetti, D. Pozzi, M. Hormozi‐Nezhad, F. Baldelli Bombelli, G. Caracciolo*, M. Mahmoudi*, “Exploring Cellular Interactions of Liposomes Using Protein Corona Fingerprints and Physicochemical Properties”, ACS Nano, 2016, 10 (3), 3723–3737.
  6. M. Mahmoudi*, S. Lohse, C. Murphy, K. Suslick*, “Variation of Protein Corona Composition of Gold Nanoparticles Following Plasmonic Heating” Nano Letters, 2014, 14 (1), 6‐12.
  7. M. Mahmoudi*, A. Ahmed, S. Behzadi, J. Clement, S. Dutz, M. Ejtehadi, R. Hartmann, K. Kantner, U. Linne, P. Maffre, S. Metzler, M. Moghadam, C. Pfeiffer, M. Rezaie, P. Ruiz‐Lozano, V. Serpooshan, M. Shokrgozar, G. U. Nienhaus, W. Parak*, “Temperature ‐ the Ignored Factor at the NanoBio Interface”, ACS Nano, 2013, 7 (8), 6555.
  8. Ho. Mao, S. Laurent, W. Chen*, O. Akhavan, M. Imani, A. Ashkarran, M. Mahmoudi*, “Graphene: Promises, Facts, Opportunities, and Challenges in Nanomedicine” Chemical Reviews, 2013, 113 (5), 3407‐3424.
  9. M. Mahmoudi*, S. Laurent, M. Shokrgozar, M. Hosseinkhani*, "Toxicity Evaluations of Superparamagnetic Iron Oxide Nanoparticles: Cell “Vision” Versus Physicochemical Properties of Nanoparticles", ACS Nano, 2011, 5(9), 7263.
  10. M. Mahmoudi*, I. Lynch, M. Ejtehadi, M. Monopoli, S. Laurent "Protein‐NPs Interactions: Opportunities and Challenges" Chemical Reviews, 2011, 111 (9), 5610– 5637 (with cover).
  11. M. Mahmoudi*, K. Azadmanesh, M. Shokrgozar, W. Journeay, S. Laurent "Effect of nanoparticles on the cell‐life cycle" Chemical Reviews, 2011, 111 (5), 3407–3432.
  12. M. Mahmoudi*, A. Ahmed, S. Behzadi, J. Clement, S. Dutz, M. Ejtehadi, R. Hartmann, K. Kantner, U. Linne, P. Maffre, S. Metzler, M. Moghadam, C. Pfeiffer, M. Rezaie, P. Ruiz‐Lozano, V. Serpooshan, M. Shokrgozar, G. U. Nienhaus, W. Parak*, “Temperature ‐ the Ignored Factor at the NanoBio Interface”, ACS Nano, 2013, 7, 6555–6562.
  13. M. Mahmoudi*, S. Bonakdar, R. Hartmann, M. Shokrgozar, H. Aghaverdi, G. Whitte, W. Parak* “Cell‐Imprinted Substrates Direct the Fate of Stem Cells”, ACS Nano, 2013, 7, 8379–838.
  14. M. Mahmoudi*, V. Serpooshan, "Silver‐Coated Engineered Magnetic Nanoparticles are Promising for the Success in the Fight against Antibacterial Resistance Threat", ACS Nano, 2012, 6, 2656–2664.
  15. M. Mahmoudi*, S. Laurent, M. Shokrgozar, M. Hosseinkhani*, "Toxicity Evaluations of Superparamagnetic Iron Oxide Nanoparticles: Cell “Vision” Versus Physicochemical Properties of Nanoparticles", ACS Nano, 2011, 5, 7263-7276.

 

Cardiac Nanotechnology

  1. M. Mahmoudi*, M. Yu, V. Serpooshan, J. Wu, R. Langer, R. Lee, J. Karp, O. Farokhzad* “Multiscale technologies for treatment of ischemic cardiomyopathy”, Nature Nanotechnology, 2017, 12, 845-855.
  2. M. Mahmoudi, A. Tachibana, A. Goldstone, Y.J. Woo, P. Chakraborty, K. Lee, C. Foote, S. Piecewicz, J. Barrozo, A. Wakeel, B. Rice, C. Bell III & P. Yang*, "Novel MRI Contrast Agent from Magnetotactic Bacteria Enables In Vivo Tracking of iPSC‐derived Cardiomyocytes", Scientific Reports, 2016, 6, 26960.
  3. K. Wei, V. Serpooshan, M. Diez‐Cunado, M. Zhao, P. Shah, P. Bushway, M. Noseda, S. Maruyama, X. Tian, P. Kim, Y. Matsuura, W. Cai, A. Savtchenko, A. Wang, W. Zhu, M. Mahmoudi, M. Schneider, B. Zhou, M. Butte, P. Yang, K. Walsh, D. Bernstein, M. Mercola, P. Ruiz‐Lozano*, “Epicardial FSTL1 Reconstitution Regenerates the Adult Mammalian Heart” Nature, 2015, 525,479–485.
  4. V. Serpooshan, M. Mahmoudi*, M. Zhao, K. Wei, S. Sivanesan, K. Motamedchaboki, A. Malkovskiy, A. Goldstone, J. Cohen, P. Yang, J. Rajadas, D. Bernstein, Y.J. Woo, P. Ruiz‐Lozano*, “Protein Corona Influences Cell‐Biomaterial Interactions in Nanostructured Tissue Engineering Scaffolds”, Advanced Functional Materials, 2015, 25(28), 4379‐4389.

 

Cancer Nanotechnology

  1. M. Mahmoudi*, O. Farokhzad* “Cancer immunotherapy: Wound-bound checkpoint blockade”, Nature Biomedical Engineering, 2017, 1, 0031.
  2. S. Zanganeh, G. Hutter, R. Spitler, O. Lenkov, M. Mahmoudi, A. Shaw, J. Pajarinen, H. Nejadnik, S. Goodman, M. Moseley, L. Coussens, H. Daldrup‐Link* “Iron oxide nanoparticles inhibit tumour growth by inducing pro‐ inflammatory macrophage polarization in tumour tissues”, Nature Nanotechnology, 2016, 11, 986–994.
  3. J. Rauch, W. Kolch*, S. Laurent, Morteza Mahmoudi*, “Big Signals from Small Particles: the Regulation of Cell Signaling Pathways by Nanoparticles” Chemical Reviews, 2013, 113 (5), 3391‐3406.
  4. S. Sharifi, S. Behzadi, S. Laurent, M.L. Forrest, P. Stroeve, M. Mahmoudi*, “Toxicity of Nanomaterials" Chemical Society Reviews, 2012, 41, 2323‐2343.
  5. M. Mahmoudi*, H. Hofmann, B. Rothen‐Rutishauser, A. Fink*, "Assessing the In vitro and In vivo Toxicity of Superparamagnetic Iron Oxide Nanoparticles" Chemical Reviews, 2012, 112 (4), 2323–233.
  6. M. Mahmoudi, S. Sant, B. Wang, S. Laurent, T. Sen "Superparamagnetic Iron Oxide Nanoparticles (SPIONs): Development, surface modification and applications in chemotherapy" Advanced Drug Delivery Reviews, 2011, 63, 24‐46.

 

Stem Cell Nanoengineering

  1. Parisa P.S.S. Abadi, Jessica C. Garbern, Shahed Behzadi, Michael J. Hill, Jason S. Tresbeck, Tiam Heydari, Mohammad Reza Ejtehadi, Nafis Ahmed, Elizabeth Copley, Haniyeh Aghaverdi, Richard T. Lee, Omid C. Farokhzad, Morteza Mahmoudi* “Engineering of Mature Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes using Substrates with Multi-Scale Topography” Advanced Functional Materials, 2018, in press.
  2. T. Heydari, M. Heidari, O. Mashinchian, M. Wojcik, K. Xu, M. Dalby, M. Mahmoudi*, M. Ejtehadi* “Development of a Virtual Cell Model to Predict Cell Response to Substrate Topography”, ACS Nano, 2017, 11, 9084-9092.
  3. M. Mahmoudi*, S. Bonakdar, R. Hartmann, M. Shokrgozar, H. Aghaverdi, G. Whitte, W. Parak* “Cell‐Imprinted Substrates Direct the Fate of Stem Cells”, ACS Nano, 2013, 7 (10), 8379–838.

 

Chemical Sensing, Sensor Arrays, Olfaction, and Molecular Recognition

  1. F. Ghasemi, M. Hormozi-Nezhad*, M. Mahmoudi* “Time-Resolved Visual Chiral Discrimination of Cysteine Using Unmodified CdTe Quantum Dots”, Scientific Reports, 2017, 7, 890.
  2. M. Mahmoudi*, S. Lohse, C. Murphy, K. Suslick*, "Identification of Nanoparticles with a Colorimetric Sensor Array", ACS Sensors, 2016, 1, 17–21.
  3. J. Askim, M. Mahmoudi, K. Suslick*, "Optical sensor arrays for chemical sensing: the optoelectronic nose", Chemical Society Reviews, 2013, 42, 8649‐8682 (with cover).

 

Neurodegenerative Nanotechnology

  1. M. Hajipour, M. Santoso, F. Rezaee, H. Aghaverdi, M. Mahmoudi*, G. Perry* “Advances in Alzheimer’s Diagnosis and Therapy: The Implications of Nanotechnology”, Trends in Biotechnology, 2017, 35, 937-953.
  2. M. Mahmoudi*, F. Quinlan‐Pluck, M. Monopoli, S. Sheibani, H. Vali, K. Dawson, I. Lynch*, "Influence of the Physiochemical Properties of Superparamagnetic Iron Oxide Nanoparticles on Amyloid", ACS Chemical Neuroscience, 2013, 4 (3), 475–485.
  3. S. Krol*, R. Macrez, F. Docagne, G. Defer, S. Laurent, M. Rahman, M. Hajipour, P. Kehoe, M. Mahmoudi*, “Therapeutic Benefits from Nanoparticles: The Potential Significance of Nanoscience in Diseases with Compromise to the Blood Brain Barrier” Chemical Reviews, 2013, 113 (3),1877‐1903.
  4. M. Mahmoudi*, K. Suslick*, “Protein fibrillation and the olfactory system: speculations on their linkage”, Trends in Biotechnology, 2012, 30 (12), 609‐610 (with cover).
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Antibacterial Nanotechnology

  1. A. Gupta, N. Saleh, R. Das, R. Landis, A. Bigdeli, K. Motamedchaboki, A. Campos, K. Pomeroy, M. Mahmoudi*, V. Rotello* “Synergistic antimicrobial therapy using nanoparticles and antibiotics for the treatment of multidrug-resistant bacterial infection”, Nano Futures, 2017, 1, 015004.
  2. M. Mahmoudi*, V. Serpooshan, "Silver‐Coated Engineered Magnetic Nanoparticles are Promising for the Success in the Fight against Antibacterial Resistance Threat", ACS Nano, 2012, 6 (3), 2656–2664.
  3. M. Hajipour, K. Fromm, A. Ashkarran, D. Jimenez de Aberasturi, I. Ruiz de Larramendi, T. Rojo, V. Serpooshan, W. Parak, M. Mahmoudi*, "Antibacterial Properties of Nanoparticles", Trends in Biotechnology, 2012, 30 (10), 499‐511.

 

Humanities and Social Sciences

  1. M. Mahmoudi* “ The need for establishment of global committee on academic behaviour ethics”, The Lancet, 2019, in press.
  2. M. Mahmoudi* “Academic bullies leave no trace”, Bioimpacts, 2019, 9 (3), 129-130.
  3. M. Mahmoudi* “Improve reporting systems for academic bullying”, Nature, 2018, 562, 494.
  4. M. Mahmoudi, S. Moss* "Tie institutions' reputations to their anti-bullying record", Nature, 2019, 572, 439.

 

Honors and Awards

  1. IGNITE Award, Connors Center for Women’s Health, Brigham and Women's Hospital, Boston, MA 2019
  2. BRI Future Prize, Brigham and Women's Hospital, Boston, MA 2019
  3. Department of Anesthesiology’s Collaborative Award), Brigham and Women's Hospital, Boston, MA 2019
  4. Stepping Strong Innovator Awards ($289,000), Brigham and Women's Hospital, Boston, MA 2018
  5. 1st Universal Scientific Education and Research Network (USERN) prize in Biological Sciences 2016
  6. Best Poster Award, Annual Scientific Session, American College of Cardiology 2016
  7. Nanoscience Research Leader Award, Publishing Division of Cognizure 2015
  8. 16th Royan International Research Award, Royan Institute 2015
  9. European Science Foundation Grant 2012
  10. European Science Foundation Grant 2011
  11. Shahid Chamran Award, National Endowment for the Elite 2011
  12. National Distinguished PhD Graduate Award, Iran Ministry of Science 2011
  13. Dr. Mojtahedi’s Innovation Award, Sharif University of Technology 2010
  14. European Science Foundation Grant 2010
  15. Scholarship Award, Iran Ministry of Science 2009
  16. 11th Kharazmi Young Festival Award, Iran Ministry of Science 2009
  17. Exceptional Talents Award, Sharif University of Technology 2008