Christiane Mallett, Ph.D.
Department of Radiology
Biomedical Physical Sciences Building
567 Wilson Rd Rm 3105
BScH (Co-op) in Biophysics from The University of Guelph
MSc in Medical Biophysics from The University of Western Ontario
PhD in Medical Biophysics from The University of Western Ontario
I am interested in the applications of cellular MRI in the diagnosis and treatment of disease. My current work involves the development of a method for earlier diagnosis of Alzheimer's disease (AD). Plaques in AD cause the release of pro-inflammatory factors by nearby cells in the brain and this leads to the recruitment of monocytes from the bone marrow to the plaques. Our goal is to label the resting monocytes with a superparamagnetic iron oxide contrast agent in vivo in a mouse model of AD. The monocytes will then migrate to the brain upon the development of inflammatory plaques, and will be detectable by using high-field MRI. My previous work was to label and track natural killer cells with a superparamagnetic iron oxide contrast agent as a treatment for prostate cancer and to use anatomical and metabolic MRI to characterize a mouse model of prostate cancer.
CIHR Frederick Banting and Charles Best Canada Graduate Scholarship – Doctoral Award (01/2009-12/2011)
1. CL Mallett, H Lim, K Thind, Y Chen, EJ. Ribot, F Martinez, TJ Scholl, P. Foster. Longitudinal anatomical and metabolic MRI characterization of orthotopic xenograft prostate tumors in nude mice. Journal of Magnetic Resonance Imaging (in press) DOI: 10.1002/jmri.24433
2. CL Mallett, Y Chen, C McFadden, PJ Foster. Migration of iron-labeled KHYG-1 natural killer cells to subcutaneous tumors in nude mice, as detected by magnetic resonance imaging. Cytotherapy. 2012 Jul;14(6):743-51
3. S de Chickera, C Willert, CL Mallett, R Foley, PJ Foster, GA Dekaban. Cellular MRI as a suitable, sensitive non-invasive modality for correlating in vivo migratory efficiencies of different dendritic cell populations with subsequent immunological outcomes. International Immunology. 2012 Jan;24(1):29-41
4. C McFadden, CL Mallett, PJ Foster. Labeling of multiple cell lines using a new iron oxide agent for cell tracking by MRI. Contrast Media and Molecular Imaging 2011; Nov-Dec; 6(6): 514-522.
5. CL Mallett, PJ Foster. Optimization of the Balanced Steady State Free Precession (bSSFP) Pulse Sequence for Magnetic Resonance Imaging of the Mouse Prostate at 3T. PLoSOne 2011 Apr 8;6(4):e18361