Jie Huang, Ph.D.
Department of Radiology
846 Service Rd Rm 184
B.S. in Physics from Peking University
M.S. in Physics from Peking University
Ph.D. in Physics from West Virginia University
Research associate, West Virginia University and Michigan State University
My current research interests focus on four areas: (1) develop novel fMRI techniques to detect brain activity-associated neuronal currents. Local neuronal currents produce transient magnetic fields that would alter local MRI signal, and this signal change directly reflects the local neuronal activity. However, it is challenging to reliably detect the MRI signal change because the effect is very small; (2) develop novel methods to determine the quantitative relationship between the elicited BOLD response and the underlying neuronal activity. Event-related BOLD-fMRI has been broadly used in brain activation studies, and understanding this relationship is essential for any quantitative interpretation of the neural events from the BOLD measurements; (3) study the neurological mechanisms of disrupted vision and visually triggered headaches in migraine. Certain patterns such as black and white stripes with a spatial frequency of about 3 cycles per degree induce many kinds of illusions and distortions, causing disrupted vision. These aversive patterns can also induce seizures in patients with photosensitive epilepsy and trigger headaches in patients with migraine. Investigating the pattern-evoked BOLD responses in the visual cortical areas offers a means to study the underlying neurological mechanisms of disrupted vision and visually triggered attacks; and (4) develop novel fMRI biomarkers to evaluate and predict effectiveness of migraine preventative treatments.
1. Jie Huang, “Detecting Neuronal Currents with MRI: A Human Study”, Magnetic Resonance in Medicine 71, 756-762 (2014).
2. Jie Huang and Yue Cao, “Functional MRI as a biomarker for evaluation and prediction of effectiveness of migraine prophylaxis”, Biomarkers in Medicine 6, 517-527 (2012).
3. Jie Huang, Tobias Hahn, Lori Hoisington, Sarah Schafer, Xiaopeng Zong, and Kevin Berger, “Improving suspicious breast lesion characterization using semi-automatic lesion fractional volume washout kinetic analysis”, Medical Physics 38, 5998-6009 (2011).
4. Xiaopeng Zong and Jie Huang, “Linear coupling of undershoot with BOLD response in ER-fMRI and nonlinear BOLD response in rapid-presentation ER-fMRI”, NeuroImage 57, 391-402 (2011).
5. Jie Huang, Xiaopeng Zong, Arnold Wilkins, Brian Jenkins, Andrea Bozoki, and Yue Cao, “fMRI evidence that precision ophthalmic tints reduce cortical hyperactivation in migraine”, Cephalalgia 31, 925-936 (2011).