Andrea Bozoki, M.D.
Department of Radiology
Clinical Center - Tower A
804 Service Rd Rm A217
B.S.: Biology, neuroscience concentration, Cornell University
Post-Graduate Pre-Medical Program: Columbia University
My lab is currently focused on studying the memory deficits that occur during the transition from normal aging to Alzheimer's disease (AD). We are studying 3 groups of individuals; healthy seniors, those with Mild Cognitive Impairment (a diagnosis that encompasses both memory-predominant and other-cognitive predominant deficits that are not severe enough to be considered dementia) and those with early stage AD. We are using event-related fMRI to visualize neural network differences between successful and unsuccessful learning attempts, both within and across groups.
The second focus of the lab is the use of a method known as DTI, which allows for evaluation of the integrity of white matter tracts. It has been established that fractional anisotropy (a measure of water diffusion along a vector) is decreased during aging in several major pathways (ie corpus callosum). It is the intention of this work to delineate whether the fornix (the main outflow pathway from the hippocampal complex) shows similar changes during aging, and could be used as a marker early in the process of converting to AD.
1. Kim SY, Karlawish JH, Kim HM, Wall IF, Bozoki AC, Appelbaum PS. Preservation of the capacity to appoint a proxy decision maker: implications for dementia research. Arch Gen Psychiatry. 2011 Feb;68(2):214-20.
2. Huang J, Zong X, Arnold Wilkins A, Jenkins B, Bozoki A, Cao Y. fMRI evidence that precision ophthalmic tints reduce cortical hyperactivation in migraine. Cephalgia. Jun 2011; 31(8):925-362011
3. Bozoki AC, Korolev IO, Davis NC, Hoisington LA, Berger KL. Disruption of Limbic White Matter Pathways in Mild Cognitive Impairment and Alzheimer’s Disease: a DTI/FDG-PET Study. Human Brain Mapping, Jun 2011; doi: 10.1002/hbm.21320
4. Zhu DC, Majumdar S, Korolev IO, Berger KL, Bozoki AC. Alzheimer’s disease and amnestic Mild Cognitive Impairment weaken connections within the Default Mode Network: a multimodal imaging study. Journal of Alzheimer’s Disease; 2013 Jan 1:34(4):969-84
5. Bozoki A, Radovanovic M, Winn B, Heeter C, Anthony JC. Effects of a computer-based cognitive exercise program on age-related cognitive decline. Arch Gerontol Geriatr. 2013 Jul-Aug;57(1):1-7.